PTC-209 |CAS:315704-66-6 Probechem Biochemicals

Chemical Structure : PTC-209

CAS No.: 315704-66-6

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PTC-209 (PTC209)

货号: PC-36171Not For Human Use, Lab Use Only.

PTC-209 (PTC209) is a specific BMI-1 inhibitor with IC50 of 0.5 uM, irreversibly impairs colorectal cancer-initiating cell (CIC) growth.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PTC-209 (PTC209) is a specific BMI-1 inhibitor with IC50 of 0.5 uM, irreversibly impairs colorectal cancer-initiating cell (CIC) growth.
PTC-209 causes cell cycle arrest at the G1/S checkpoint in biliary tract cancer (BTC) cells, decreases BMI1 and increases p16 protein expression in canine OSA cell lines.
PTC-209 reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.

物理化学性质&存储条件

分子量	495.2
分子式	C17H13Br2N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

参考文献

1. Kreso A, et al. Nat Med. 2014 Jan;20(1):29-36.

2. Mourgues L, et al. Leukemia. 2015 Oct;29(10):1993-2002.

3. Nishida Y, et al. Cancer Sci. 2015 Dec;106(12):1705-13.

4. Mayr C, et al.Oncotarget. 2016 Jan 5;7(1):745-58.

PTC-209 (PTC209)

生物&药学活性

物理化学性质&存储条件

参考文献

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PTC-209 (PTC209)

生物&药学活性

物理化学性质&存储条件

参考文献

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