PTC-124 | Readthrough promoter | Probechem Biochemicals

Chemical Structure : PTC-124

CAS No.: 775304-57-9

加入收藏

PTC-124 (Ataluren)

货号: PC-21295Not For Human Use, Lab Use Only.

PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.

规格	价格	库存
50 mg	￥1580	In stock
100 mg	￥2580	In stock
200 mg	￥3980	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.
PTC-124 (Ataluren) promotes suppression of the human CFTR-G542X nonsense allele in cystic fibrosis (CF) mouse model.
PTC-124 (Ataluren) is a potent firefly luciferase (FLuc) inhibitor with IC50 of 7 nM.
PTC-124 (Ataluren) promotes ribosomal readthrough of premature stop codons in mRNA and offers therapeutic potential for multiple genetic diseases.

物理化学性质&存储条件

分子量	284.25
分子式	C15H9FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

参考文献

1. Auld DS, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3585-90.

2. Du M, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2064-9.

3. Welch EM, et al. Nature. 2007 May 3;447(7140):87-91.

PTC-124 (Ataluren)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PTC-124 (Ataluren)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.