PTC-028 | BMI-1 inhibitor | Probechem Biochemicals

Chemical Structure : PTC-028

CAS No.: 1782970-28-8

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PTC-028 (PTC 028, PTC028)

货号: PC-60464Not For Human Use, Lab Use Only.

PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

PTC-028 (PTC028) is a novel potent, selective, orally bioavailable BMI-1 inhibitor with potent anti-MM activity against primary MM cells (IC50=10-100 nM).
PTC-028 decreases BMI-1 levels by posttranslational modification, selectively inhibits cancer cells in clonal growth and viability assays (IC50=100 nM), without effeccts on normal cells.
PTC-028 exhibits significant antitumor activity in mouse model of ovarian cancer.

物理化学性质&存储条件

分子量	405.332
分子式	C19H12F5N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(5,6-difluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)pyrazin-2-amine

参考文献

1. Dey A, et al. Mol Cancer Ther. 2017 Nov 20. doi: 10.1158/1535-7163.MCT-17-0574.

PTC-028 (PTC 028, PTC028)

生物&药学活性

物理化学性质&存储条件

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PTC-028 (PTC 028, PTC028)

生物&药学活性

物理化学性质&存储条件

参考文献

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