PTB1 | BamA inhibitor | Probechem Biochemicals

Chemical Structure : PTB1

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PTB1 (Peptide Targeting BamA-1)

货号: PC-23126Not For Human Use, Lab Use Only.

Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.

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生物&药学活性

Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.
PTB1 exhibits MICs against wild-type Klebsiella pneumoniae and Enterobacter cloacae, ranging from 42 to 168 µg/mL (25–100 µM), shows no MICs against the non-fermenting Gram-negative pathogens Pseudomonas aeruginosa and Acinetobacter baumannii.
PTB1-1 reduces OMP levels, decreases activity of the OmpT enzyme that requires BAM for folding, and increases OM permeability.
PTB1 targets an extracellular binding site, and acts as a state-dependent antagonist which targets the closed state of BamA.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Sun D, et al. Nat Commun. 2024 Oct 8;15(1):8718.

PTB1 (Peptide Targeting BamA-1)

生物&药学活性

物理化学性质&存储条件

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PTB1 (Peptide Targeting BamA-1)

生物&药学活性

物理化学性质&存储条件

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