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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-PST inhibitor peptide-8
PST inhibitor peptide-8

Chemical Structure : PST inhibitor peptide-8

CAS No.:

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PST inhibitor peptide-8 (PSTi8)

货号: PC-49842Not For Human Use, Lab Use Only.

PST inhibitor peptide-8 (PSTi8) is a potent pancreastatin (PST) inhibitor, competes with PST on GRP78 receptor binding and rescues PST-induced insulin resistance (IR) both in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PST inhibitor peptide-8 (PSTi8) is a potent pancreastatin (PST) inhibitor, competes with PST on GRP78 receptor binding and rescues PST-induced insulin resistance (IR) both in vitro and in vivo.
    PST (100 nM) was found to inhibit >50% binding of labelled PSTi8 (150 nM) and PSTi8 (300 nM) was found to inhibit >50% binding of labelled PST (25 nM).
    PST (100 nM) inhibits protein expression of GRP78 in tunicamycin stimulated condition in HepG2 cells, which is significantly inhibited by PSTi8 (800 nM), PSTi8 also enhances tunicamycin effect on stimulation of GRP78 protein expression.
    PSTi8 regulates secreation of biomolecule, glycogen storage and hepatic gene expression.
    PSTi8 acute (i.p, 5 mg/kg) and chronic (i.p, 2 mg/kg for 7 days), administration attenuates IR in HFD-fed, HFrD-fed and db/db diabetic mice.

    物理化学性质&存储条件

    分子量 2041.18
    分子式 C83H133N25O33S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Sequence: PEGKGEQEHSQQKEEEEEMAV-amide

    参考文献

    1. Hossain Z, et al. Sci Rep. 2018 Jun 7;8(1):8715.

    2. Valicherla GR, et al. Peptides. 2019 Oct;120:170147.

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