PSTC | Nrf2 activator | Probechem Biochemicals

Chemical Structure : PSTC

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PSTC (Nrf2 activator PSTC)

货号: PC-60630Not For Human Use, Lab Use Only.

PSTC is a potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).

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生物&药学活性

PSTC is a potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).
PSTC induces Nrf2 nuclear translocation, Nrf2-regulated gene expression, and downstream signaling events, including induction of NAD(P)H:NQO1 enzyme activity and heme oxygenase-1 protein expression, in an Nrf2-dependent manner.
PSTC does not inhibit IL-1β-induced NF-κB translocation or insulin-induced S6 phosphorylation in human cells.
PSTC restores oxidant (tert-butyl hydroperoxide)-induced glutathione depletion in vitro and in vivo models of pulmonary oxidative stress.

物理化学性质&存储条件

分子量	355.287
分子式	C15H8F3NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one

参考文献

1. Yonchuk JG, et al. J Pharmacol Exp Ther. 2017 Aug 8. pii: jpet.117.241794.

PSTC (Nrf2 activator PSTC)

生物&药学活性

物理化学性质&存储条件

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PSTC (Nrf2 activator PSTC)

生物&药学活性

物理化学性质&存储条件

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