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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -PST3093
PST3093

Chemical Structure : PST3093

CAS No.: 2805980-42-9

PST3093 (PST 3093)

货号: PC-49733Not For Human Use, Lab Use Only.

PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM.
    PST3093 shows a longer half-life in human circulation compared with parent drug Istaroxime.
    PST3093 did not inhibit the Na+/K+ ATPase activity up to 100 µM, and no INaK inhibition.
    PST3093 and istaroxime equally stimulated SERCA2a ATPase activity in preparations including PLN.
    PST3093 selectively activates SERCA2a, and improves cardiac performance in a model of diabetic cardiomyopathy.

    物理化学性质&存储条件

    分子量 377.48
    分子式 C21H31NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E,Z)-[(6-beta-hydroxy-17-oxoandrostan-3-ylidene)amino]oxyacetic acid

    参考文献

    1. Martina Arici, et al. J Pharmacol Exp Ther. 2023 Jan;384(1):231-244.

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