PST-3 | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : PST-3

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PST-3 (Microtubule inhibitor PST-3)

货号: PC-72173Not For Human Use, Lab Use Only.

PST-3 (Microtubule inhibitor PST-3) is a novel microtubule inhibitor exhibited broad-spectrum cellular cytotoxicity and in vivo potency with high safety.

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生物&药学活性

PST-3 (Microtubule inhibitor PST-3) is a novel microtubule inhibitor exhibited broad-spectrum cellular cytotoxicity and in vivo potency with high safety.
PST-3 inhibits different cancer cell with high safety (BT549 IC50=15 uM, MDA-MB-468 IC50=16 uM), inhibits human breast cancer cell clonogenic growth with IC50 values rang from 3 uM to 25 uM (MDA-MB-231 cell IC50=11.43 uM).
PST-3 binds to the colchicine binding site on microtubule, induces morphological changes, disrupts the structure of microtubule in cells and inhibits tubulin polymerization, arrests BT549 and MDA-MB-468 cells in G2/M phase.
PST-3 shows preferential growth inhibition in triple-negative breast cancer xenografts growth without neurotoxicity in vivo.

物理化学性质&存储条件

分子量	376.47
分子式	C23H20O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(3, 4-Dimethoxy)-benzoyl)-(5-(4-ethyl)-phenylethynyl)-thiophene

参考文献

1. Yuxin Zhuang, et al. Am J Cancer Res. 2022 Jan 15;12(1):229-246.

PST-3 (Microtubule inhibitor PST-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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PST-3 (Microtubule inhibitor PST-3)

生物&药学活性

物理化学性质&存储条件

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