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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-PSNCBAM-1
PSNCBAM-1

Chemical Structure : PSNCBAM-1

CAS No.: 877202-74-9

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PSNCBAM-1 (PSNCBAM 1)

货号: PC-72731Not For Human Use, Lab Use Only.

PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM.

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5 mg ￥1180 In stock
10 mg ￥1780 In stock
25 mg ￥2780 In stock
50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM. PSNCBAM-1 does not affect CB2 receptors.
PSNCBAM-1 blocked the effects induced by agonists such as CP55,940, WIN55212-2, anandamide (AEA) or 2-arachidonoyl glycerol (2-AG) in CB1 receptor yeast reporter assays.
PSNCBAM-1 decreased food intake and body weight in an acute rat feeding model.

物理化学性质&存储条件

分子量 392.887
分子式 C22H21ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 nM in DMSO
Chemical Name/SMILES

1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea

参考文献

1. Horswill JG, Br J Pharmacol. 2007 Nov;152(5):805-14.

2. Wang X, et al. Mol Pharmacol. 2011 Apr;79(4):758-67.

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