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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-PSN-GK1
PSN-GK1

Chemical Structure : PSN-GK1

CAS No.: 745051-61-0

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PSN-GK1 (PSN GK1)

货号: PC-61876Not For Human Use, Lab Use Only.

PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold).
    PSN-GK1  increases MIN6 insulin secretion (26-fold, EC50=267 nM) and 2-DG hepatocytic uptake (3-fold, EC50=1 uM).
    PSN-GK1  displays enhanced antihyperglycaemic and insulinotropic actions in mice.

    物理化学性质&存储条件

    分子量 438.532
    分子式 C20H23FN2O4S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R)-2-(4-cyclopropanesulfonylphenyl)- N-(5-fluorothiazol-2-yl)-3-(tetrahydropyran-4-yl)propionamide

    参考文献

    1. Fyfe MC, et al. Diabetologia. 2007 Jun;50(6):1277-87.

    2. Bertram LS, et al. J Med Chem. 2008 Jul 24;51(14):4340-5.

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