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PSI-6130

Chemical Structure : PSI-6130

CAS No.: 817204-33-4

PSI-6130 (PSI6130, R-1656, R1656)

货号: PC-42412Not For Human Use, Lab Use Only.

PSI-6130 (R-1656) is a potent, specific inhibitor of HCV RNA synthesis by inhibiting the NS5B RNA polymerase (EC90=4.6 uM in replicon assay).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PSI-6130 (R-1656) is a potent, specific inhibitor of HCV RNA synthesis by inhibiting the NS5B RNA polymerase (EC90=4.6 uM in replicon assay).
PSI-6130 shows no anti-BVDV activity and weak antiviral activity against other flaviviruses, including West Nile virus, Dengue type 2, and yellow fever virus.
PSI-6130 has little or no cytotoxicity against various cell type.

物理化学性质&存储条件

分子量 259.2343
分子式 C10H14FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-

参考文献

1. Clark JL, et al. J Med Chem. 2005 Aug 25;48(17):5504-8.

2. Murakami E, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):503-9.

3. Stuyver LJ, et al. Antivir Chem Chemother. 2006;17(2):79-87.

4. Ma H, et al. J Biol Chem. 2007 Oct 12;282(41):29812-20.

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