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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-PSFL1191
PSFL1191

Chemical Structure : PSFL1191

CAS No.: 38969-48-1

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PSFL1191 (PSFL-1191)

货号: PC-25895Not For Human Use, Lab Use Only.

PSFL1191 is a potent, species-specific inhibitor for human and panda P2X7 receptors with IC50 of 248 nM (hP2X7) and 754 nM (pdP2X7), but inactive against rodents P2X7 (mP2X7/rP2X7, IC50>30 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PSFL1191 is a potent, species-specific inhibitor for human and panda P2X7 receptors with IC50 of 248 nM (hP2X7) and 754 nM (pdP2X7), but inactive against rodents P2X7 (mP2X7/rP2X7, IC50>30 uM).
PSFL1191 shows high selectivity over hP2X1, hP2X2, and hP2X3.
PSFL1191 markedly altered macrophage-mediated bacterial clearance and wound healing while preserving basal physiology in P2rx7A312V/A312V mice.

物理化学性质&存储条件

分子量 379.46
分子式 C23H25NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(13S,13aR)-13-allyl-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

参考文献

1. Guo CR, et al. Nat Commun. 2025 Dec 2;16(1):10827.

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