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首页-小分子抑制剂&激动剂-Others-Other Targets-PSB-KK1445
PSB-KK1445

Chemical Structure : PSB-KK1445

CAS No.: 885896-54-8

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PSB-KK1445 (PSB-KK 1445)

货号: PC-22541Not For Human Use, Lab Use Only.

PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55.

物理化学性质&存储条件

分子量 446.49
分子式 C24H23FN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-fluorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Andhika B Mahardhika, et al. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. 

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