PSB-KK1415 | GPR18 agonist | Probechem Biochemicals

Chemical Structure : PSB-KK1415

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PSB-KK1415 (PSB-KK-1415)

货号: PC-21097Not For Human Use, Lab Use Only.

PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.

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生物&药学活性

PSB-KK1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.
PSB-KK1415 displays >25-fold selectivity versus CB receptors, and shows minimal species differences.
PSB-KK1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.

物理化学性质&存储条件

分子量	462.94
分子式	C24H23ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-chlorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Fabisiak A, et al. Neurogastroenterol Motil. 2021 Mar;33(3):e14003.
2. Andhika B Mahardhika, et al. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423.

PSB-KK1415 (PSB-KK-1415)

生物&药学活性

物理化学性质&存储条件

参考文献

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PSB-KK1415 (PSB-KK-1415)

生物&药学活性

物理化学性质&存储条件

参考文献

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