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首页-小分子抑制剂&激动剂-Others-Other Targets-PSB-KD107
PSB-KD107

Chemical Structure : PSB-KD107

CAS No.: 955121-65-0

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PSB-KD107 (PSB-KD-107)

货号: PC-49030Not For Human Use, Lab Use Only.

PSB-KD107 is a potent, selective GPR18 receptor agonist with EC50 of 0.562 uM and 1.78 uM for human and mouse GPR18, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PSB-KD107 is a potent, selective GPR18 receptor agonist with EC50 of 0.562 uM and 1.78 uM for human and mouse GPR18, respectively.
    PSB-KD107 produces concentration-dependent relaxation in phenylephrine-precontracted endothelium-intact aortic rings with pIC50 of 5.22.
    PSB-KD107 exerts vascular activity and produces total relaxation of phenylephrine-pre-contracted rat aorta.

    物理化学性质&存储条件

    分子量 378.436
    分子式 C20H22N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    9-(2-(1H-indol-3-yl)ethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[2,1-f]purine-2,4(1H,3H)-dione

    参考文献

    1. Magdalena Kotańska, et al. Pharmaceuticals (Basel). 2021 Aug 13;14(8):799.
    2. Andhika B Mahardhika, et al. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. 

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