PSB-CB-27 | GPR18 antagonist | Probechem Biochemicals

Chemical Structure : PSB-CB-27

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PSB-CB-27 (GPR18 antagonist PSB-CB-27)

货号: PC-49029Not For Human Use, Lab Use Only.

PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors.

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生物&药学活性

PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors.
PSB-CB-27 showed improved selectivity versus CB receptors as compared to PSB-CB5.
PSB-CB-27 shows a complete blockade of THC-induced GPR18 activation and is thus a superior tool for target validation, compared with partial inhibition by PSB-CB5.
PSB-CB-27 exhibits a pIC50 of 6.2 at the hGPR18 in the β-arrestin recruitment assays.

物理化学性质&存储条件

分子量	471.012
分子式	C25H27ClN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one

参考文献

1. Schoeder CT, et al. Eur J Med Chem. 2018 Jul 15;155:381-397.

2. Kozłowska H, et al. Int J Mol Sci. 2022 Jan 26;23(3):1427.

PSB-CB-27 (GPR18 antagonist PSB-CB-27)

生物&药学活性

物理化学性质&存储条件

参考文献

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PSB-CB-27 (GPR18 antagonist PSB-CB-27)

生物&药学活性

物理化学性质&存储条件

参考文献

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