PSB-22040 | MRGPRX4 agonist | Probechem Biochemicals

Chemical Structure : PSB-22040

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PSB-22040 (PSB22040, PSB 22040)

货号: PC-21319Not For Human Use, Lab Use Only.

PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.

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生物&药学活性

PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
PSB-22040 shows high selectivity over the other MRGPRX subtypes, MRGPRX1, -2, and -3.
PSB-22040 is a promising tool compound for exploring the potential of MRGPRX4 as a future drug target.

物理化学性质&存储条件

分子量	474.45
分子式	C22H27N4O6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(8-(3-Methoxyphenethyl)-7-methyl-2,6-dioxo-1-(prop-2-yn-1-yl)-1,2,6,7-tetrahydro-3H-purin-3-yl)butyl)phosphonic Acid

参考文献

1. Marx D, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c01013.

PSB-22040 (PSB22040, PSB 22040)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PSB-22040 (PSB22040, PSB 22040)

生物&药学活性

物理化学性质&存储条件

参考文献

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