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首页-小分子抑制剂&激动剂-GPCR-GPR84-PSB-16671
PSB-16671

Chemical Structure : PSB-16671

CAS No.: 2094630-35-8

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PSB-16671 (PSB16671)

货号: PC-72359Not For Human Use, Lab Use Only.

PSB-16671 is a novel orthosteric and allosteric activator of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PSB-16671 is a novel orthosteric and allosteric activator of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays.
    PSB-16671 is selective versus related fatty acid receptors and the arylhydrocarbon receptor.
    PSB-16671 shows an EC50 of 5.47 uM in β-Arrestin assays, and allosteric KB value of 634 nM.

    物理化学性质&存储条件

    分子量 318.275
    分子式 C17H10F4N2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    di(5,7-difluoro-1H-indole-3-yl)methane

    参考文献

    1. Sarah J Mancini, et al. Sci Rep. 2019 Feb 12;9(1):1861.
    2. Pillaiyar T, et al. J Med Chem. 2017 May 11;60(9):3636-3655.

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