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PSB-12379

Chemical Structure : PSB-12379

CAS No.: 1802226-78-3

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PSB-12379 (PSB12379)

货号: PC-62916Not For Human Use, Lab Use Only.

PSB-12379 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.03/2.21 nM for rat/human recombinant eN.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PSB-12379 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.03/2.21 nM for rat/human recombinant eN.
PSB-12379 displays high selectivity versus other ecto-nucleotidases and ADP-activated P2Y receptors, has high metabolic stability.

物理化学性质&存储条件

分子量 515.36
分子式 C18H23N5O9P2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(((((2R,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid

参考文献

1. Bhattarai S, et al. J Med Chem. 2015 Aug 13;58(15):6248-63.

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