PS423 (PS-423, PS 423) | PDK1 inhibitor | Probechem Biochemicals

Chemical Structure : PS423

CAS No.: 1221964-37-9

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PS423 (PS 423, PS-423)

货号: PC-62480Not For Human Use, Lab Use Only.

PS423 (PS-423, PS 423) is a substrate-selective inhibitor of Phosphoinositide-dependent protein kinase 1 (PDK1), inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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生物&药学活性

PS423 (PS-423, PS 423) is a substrate-selective inhibitor of Phosphoinositide-dependent protein kinase 1 (PDK1), inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
PS423 inhibits glucose uptake in C2C12 myoblasts.
PS423 inhibits S6K but not PKB/Akt downstream signaling in muscle cells.

物理化学性质&存储条件

分子量	524.445
分子式	C25H23F3O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Bis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate

参考文献

1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.

2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

PS423 (PS 423, PS-423)

生物&药学活性

物理化学性质&存储条件

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PS423 (PS 423, PS-423)

生物&药学活性

物理化学性质&存储条件

参考文献

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