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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-PRX-177561
PRX-177561

Chemical Structure : PRX-177561

CAS No.:

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PRX-177561 (PRX177561;PRX 177561)

货号: PC-60339Not For Human Use, Lab Use Only.

PRX-177561 is a novel potent, selective, brain-penetrating, orally active CXCR4 antagonist with Ki of 3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PRX-177561 is a novel potent, selective, brain-penetrating, orally active CXCR4 antagonist with Ki of 3 nM.
PRX-177561 inhibits tumor growth alone, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma.
PRX-177561 reduces the expression of Nestin in vivo, reduces tumor cell proliferation and accelerates cancer stem cell differentiation in glioblastoma preclinical models.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Gravina GL, et al. J Hematol Oncol. 2017 Jan 5;10(1):5.

2. Gravina GL, et al. Tumour Biol. 2017 Jun;39(6):1010428317695528.

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