欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-PRT062607 hydrochloride
PRT062607 hydrochloride

Chemical Structure : PRT062607 hydrochloride

CAS No.: 1370261-97-4

加入收藏

PRT062607 hydrochloride (BIIB057, P505-15, PRT-062607 hydrochloride)

货号: PC-22082Not For Human Use, Lab Use Only.

PRT062607 (P505-15) hydrochloride is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PRT062607 (P505-15) hydrochloride is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 displays 80-fold greater than its affinity for other kinases.
PRT062607 potently inhibit SYK- and BCR-dependent activation of normal B-cells.
PRT062607 successfully inhibits SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL.
PRT062607 prevents BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model.

物理化学性质&存储条件

分子量 429.91
分子式 C19H24ClN9O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride

参考文献

1. Spurgeon SE, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.

2. Rasool S, et al. Sci Rep. 2024 Apr 2;14(1):7739.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: