PRT062607 (P505-15) | Syk inhibitor, PINK1 inhibitor | Probechem Biochemicals

Chemical Structure : PRT062607

CAS No.: 1370261-96-3

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PRT062607 (BIIB057, P505-15, PRT-062607)

货号: PC-22081Not For Human Use, Lab Use Only.

PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 displays 80-fold greater than its affinity for other kinases.
PRT062607 potently inhibit SYK- and BCR-dependent activation of normal B-cells.
PRT062607 successfully inhibits SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL.
PRT062607 prevents BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model.

物理化学性质&存储条件

分子量	393.46
分子式	C19H23N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide

参考文献

1. Spurgeon SE, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.

2. Rasool S, et al. Sci Rep. 2024 Apr 2;14(1):7739.

PRT062607 (BIIB057, P505-15, PRT-062607)

生物&药学活性

物理化学性质&存储条件

参考文献

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PRT062607 (BIIB057, P505-15, PRT-062607)

生物&药学活性

物理化学性质&存储条件

参考文献

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