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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-PRN473
PRN473

Chemical Structure : PRN473

CAS No.: 1581714-49-9

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PRN473 (Atuzabrutinib, SAR 444727, PRN-473)

货号: PC-38012Not For Human Use, Lab Use Only.

PRN473 (Atuzabrutinib, SAR 444727, PRN-473) is a potent, selective, covalent reversible BTK inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PRN473 (Atuzabrutinib, SAR 444727, PRN-473) is a potent, selective, covalent reversible BTK inhibitor.
    PRN473 demonstrates in vivo efficacy in rodent arthritis models, and clinical efficacy in canine pemphigus foliaceus. PRN473 has completed phase 1 trials as a topical agent.

    物理化学性质&存储条件

    分子量 539.615
    分子式 C30H30FN7O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R,E)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

    参考文献

    1. Herter JM, et al. Br J Pharmacol. 2018;175(3):429-439.

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