PRN371 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : PRN371

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PRN371 (PRN 371, PRN-371)

货号: PC-62557Not For Human Use, Lab Use Only.

PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2.

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生物&药学活性

PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2.
PRN371 effectively inhibits IL-2 induces JAK1/3-STAT5 phosphorylation in PBMCs with IC50 of 99 nM, effectively blocks JAK3-mediated signaling in JAK3-driven cancer cells.
PRN371 effectively inhibits the growth of NKTL cells via suppressing the JAK3-STAT pathway, and exhibits a more durable inhibition on JAK3 compared to tofacitinib in vitro.
PRN371 significantly inhibits tumor growth in NKTL xenograft model harboring JAK3 activating mutation.

物理化学性质&存储条件

分子量	363.421
分子式	C20H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-acrylamidophenyl)-N-(tert-butyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

参考文献

1. Nairismägi M-, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0004-x.

PRN371 (PRN 371, PRN-371)

生物&药学活性

物理化学性质&存储条件

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PRN371 (PRN 371, PRN-371)

生物&药学活性

物理化学性质&存储条件

参考文献

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