Rilzabrutinib (PRN1008) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : PRN1008

CAS No.: 1575596-29-0

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PRN1008 (Rilzabrutinib, PRN-1008)

货号: PC-62583Not For Human Use, Lab Use Only.

Rilzabrutinib (PRN1008) is a potent, selective, covalent reversible BTK inhibitorwith IC50 of 1.3 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

Rilzabrutinib (PRN1008) is a potent, selective, covalent reversible BTK inhibitorwith IC50 of 1.3 nM.
PRN1008 displays highly selectively when tested in a panel of 251 other kinases.
PRN1008 inhibits anti-IgM induces human B cell proliferation (10% serum) and B cell CD69 expression, with IC50s of 5 nM and 123 nM, respectively.
Rilzabrutinib (PRN1008) demonstrates in vivo efficacy in rodent arthritis models, and clinical efficacy in canine pemphigus foliaceus.
Rilzabrutinib (PRN1008) is in phase 3 trials for pemphigus vulgaris and immune thrombocytopenia.

物理化学性质&存储条件

分子量	665.774
分子式	C36H40FN9O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile

参考文献

1. Smith PF, et al. Br J Clin Pharmacol. 2017 Nov;83(11):2367-2376.

PRN1008 (Rilzabrutinib, PRN-1008)

生物&药学活性

物理化学性质&存储条件

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PRN1008 (Rilzabrutinib, PRN-1008)

生物&药学活性

物理化学性质&存储条件

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