PRN-1371 |CAS:1802929-43-6 Probechem Biochemicals

Chemical Structure : PRN-1371

CAS No.: 1802929-43-6

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PRN-1371 (PRN1371)

货号: PC-60073Not For Human Use, Lab Use Only.

PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.

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10 mg	￥2880	In stock
25 mg	￥4580	In stock
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生物&药学活性

PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.
PRN-1371 demonstrates excellent kinome-wide selectivity in a number of biochemical and cellular assays.
PRN-1371 exhibits sustained inhibition of FGFR in multiple tumor xenografts and patient-derived tumor xenograft models.

物理化学性质&存储条件

分子量	561.464
分子式	C26H30Cl2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Brameld KA, et al. J Med Chem. 2017 Aug 10;60(15):6516-6527.

2. Venetsanakos E, et al. Mol Cancer Ther. 2017 Dec;16(12):2668-2676.

PRN-1371 (PRN1371)

生物&药学活性

物理化学性质&存储条件

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PRN-1371 (PRN1371)

生物&药学活性

物理化学性质&存储条件

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