PRMT9 inhibitor LD2

Chemical Structure : PRMT9 inhibitor LD2

CAS No.: 1134334-55-6

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货号: PC-22354Not For Human Use, Lab Use Only.

PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PRMT9 inhibitor LD2 is a specific small molecule PRMT9 inhibitor, inhibits PABPC1 R493 methylation level with IC50 of 0.9 uM in in Molm13s, sparing other PRMTs.
LD2 binds PRMT9 (−7.15 kcal mol−1) with greater affinity than the other PRMTs tested.
LD2 treatment preferentially inhibited the viability of cancer cells and their protein synthesis.
LD2 treatment (2.5 uM) expanded the number of IFN-γ-expressing T cells relative to vehicle controls in AML mononuclear cells (MNCs), without effect on T cell viability.
LD2 synergizes with anti-programmed cell death protein 1 in eradicating AML.

物理化学性质&存储条件

分子量	247.68
分子式	C12H10ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole

参考文献

1. Dong H, et al. Nat Cancer. 2024 Apr;5(4):601-624.