PRMT1 activator TR-07

Chemical Structure : PRMT1 activator TR-07

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货号: PC-28112Not For Human Use, Lab Use Only.

PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro.
TR-07 binds to the αY helix near the catalytic core of PRMT1.
TR-07 enhances the sensitivity to gemcitabine-induced apoptosis in PDAC tumor cells.
TR-07 enhances global ADMA levels in pancreatic tumor cells and augments PRMT1's apoptotic function in cell culture and mouse models.

物理化学性质&存储条件

分子量	335.41
分子式	C20H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(((3-((dimethylamino)methyl)benzyl)amino)methylene)isoquinoline-1,3(2H,4H)-dione

参考文献

1. Salehipour-Bavarsad S, et al. J Med Chem. 2026 Sep 10;69(17):20116-20137.