PRLthiophenib

Chemical Structure : PRLthiophenib

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货号: PC-25611Not For Human Use, Lab Use Only.

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生物&药学活性

PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM.
PRLthiophenib is selective over Vaccinia H1-related (VHR) phosphatas, protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP).
PRLthiophenib rescues PRL-3-induced cell death in a three-dimensional PRL-3 expressing rescues PRL-3-induced mouse derived small intestine (SI) organoids.

物理化学性质&存储条件

分子量	447.51
分子式	C25H21NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methylbenzyl (E)-3-(3-(5-acetylthiophen-2-yl)-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylate

参考文献

1. Hoffmann A, et al. Bioorg Med Chem. 2025 Sep 23;131:118412.

PRLthiophenib

生物&药学活性

物理化学性质&存储条件

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PRLthiophenib

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物理化学性质&存储条件

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