PRL inhibitor Cmpd-43 | PRL inhibitor | Probechem Biochemicals

Chemical Structure : PRL inhibitor Cmpd-43

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PRL inhibitor Cmpd-43 (Cmpd-43)

货号: PC-21504Not For Human Use, Lab Use Only.

PRL inhibitor Cmpd-43 is a specific small molecule inhibitor and detrimerizer of phosphatase of regenerating liver (PRL), significantly decreases PRL1 trimer formation inside the cell.

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生物&药学活性

PRL inhibitor Cmpd-43 is a specific small molecule inhibitor and detrimerizer of phosphatase of regenerating liver (PRL), significantly decreases PRL1 trimer formation inside the cell.
PRL inhibitor Cmpd-43 (20 uM) does not inhibit the phosphatase activity of PRL1 as well as a large panel of PTPs including receptor-like PTPs, PTPμ, PTPε, LAR, PTPσ and PTPγ, cytosolic PTPs, PTP1B, Lyp, SHP1, PTPH1, HePTP, STEP, and PEZ, the dual specificity phosphatase VHR, VHZ, MKP5, CDC14A, and the low molecular weight PTP.
Cmpd-43 (0.1-50 uM) inhibits PRL1 induced cell proliferation and migration in a dose dependent manner in PRL1 expressing HEK293 cells.
Cmpd-43 also markedly delays the wound closure induced by PRL1 overexpression.
Cmpd-43 exerts anti-proliferative activity through blocking PRL1 trimerization.
Cmpd-43 inhibits PRL1-induced ERK1/2 and Akt activation in MeWo cells by blocking PRL1 trimerization.
Cmpd-43 (30 mg/kg) suppresses melanoma xenograft growth in vivo.
Cmpd-43 phenocopies the effect of genetic deletion of Prl2 and reduces Tp53 deficiency-induced tumor growth.

物理化学性质&存储条件

分子量	413.48
分子式	C25H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-((2-(3-(5,6-dimethylisoindolin-2-yl)benzoyl)hydrazineylidene)methyl)benzoic acid

参考文献

1. Yunpeng Bai, et al. Cancer Res. 2016 Aug 15;76(16):4805-15.

2. Nguele Meke F, et al. Cancer Res Commun. 2023 Dec 2. doi: 10.1158/2767-9764.CRC-23-0308.

PRL inhibitor Cmpd-43 (Cmpd-43)

生物&药学活性

物理化学性质&存储条件

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PRL inhibitor Cmpd-43 (Cmpd-43)

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物理化学性质&存储条件

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