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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-PRL-295
PRL-295

Chemical Structure : PRL-295

CAS No.: 2377770-85-7

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PRL-295 (PRL295)

货号: PC-72862Not For Human Use, Lab Use Only.

PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor.
    PRL-295 binds to Keap1 in the cellular environment, disrupting its interaction with Nrf2, which leads to enhanced gene expression of the classical Nrf2 target NQO1 in cells and in vivo in the mouse liver.
    PRL-295 increases the thermostability of Keap1 in cell lysates and in live cells.
    PRL-295 decreased the levels of plasma alanine aminotransferase and aspartate aminotransferase upon acetaminophen-induced hepatic injury.

    物理化学性质&存储条件

    分子量 639.617
    分子式 C27H24F3N3O8S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((4-methoxy-N-(2,2,2-trifluoroethyl)phenyl)sulfonamido)isoquinolin-1-yl)-N-((4-methoxyphenyl)sulfonyl)glycine

    参考文献

    1. Dayalan Naidu S, et al. iScience. 2021 Dec 27;25(1):103703.

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