PRI-724 |CAS 847591-62-2 Probechem Biochemicals

Chemical Structure : PRI-724

CAS No.: 1422253-38-0

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PRI-724 (Foscenvivint;OP-724;PRI724;OP724)

货号: PC-70120Not For Human Use, Lab Use Only.

PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
PRI-724 (OP-724) binds specifically to the co-activator CBP, but not to p300.
PRI-724 (OP-724) selectively induces apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.

物理化学性质&存储条件

分子量	658.65
分子式	C33H35N6O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate

参考文献

1. Sasaki T, et al. Transl Respir Med. 2014 Sep 11;2:8.

2. Zhang X, et al. Am J Cancer Res. 2015 Jul 15;5(8):2344-60.

PRI-724 (Foscenvivint;OP-724;PRI724;OP724)

生物&药学活性

物理化学性质&存储条件

参考文献

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PRI-724 (Foscenvivint;OP-724;PRI724;OP724)

生物&药学活性

物理化学性质&存储条件

参考文献

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