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首页-小分子抑制剂&激动剂-Others-Other Targets-PRGL493
PRGL493

Chemical Structure : PRGL493

CAS No.: 2479378-45-3

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PRGL493 (PRGL 493)

货号: PC-38301Not For Human Use, Lab Use Only.

PRGL493 (PRGL 493) is a potent selective inhibitor of Acyl-CoA synthetase 4 (ACSL4).

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PRGL493 (PRGL 493) is a potent selective inhibitor of Acyl-CoA synthetase 4 (ACSL4).
PRGL493 inhibited the proliferation of highly aggressive breast and prostate cancer cells with IC50 of 23 uM and 27 uM, respectively.
PRGL493 blocked cell proliferation and tumor growth in both breast and prostate cellular and animal models and sensitized tumor cells to chemotherapeutic and hormonal treatment.
PGRL493 inhibited de novo steroid synthesis in testis and adrenal cells, in a mouse model and in prostate tumor cells.

物理化学性质&存储条件

分子量 451.49
分子式 C25H21N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide

参考文献

1. Ana F Castillo, et al. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910.

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