PRDX1 inhibitor H7 | PRDX1 inhibitor | Probechem Biochemicals

Chemical Structure : PRDX1 inhibitor H7

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PRDX1 inhibitor H7 (Peroxiredoxin I inhibitor H7)

货号: PC-22248Not For Human Use, Lab Use Only.

PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.

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生物&药学活性

PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.
H7 directly and non-covalently binds to Prdx I but not to Prdxs II-V in cells.
Knockdown or overexpression of Prdx I increases or decreases H7-induced cell differentiation, H7 induces partial differentiation of NB4 cells.
H7 induces cell differentiation of non-APL leukemia cell lines and primary cells, through activation of the ROS-Erk1/2-C/EBPβ pathway.
H7 (10 mg/kg, 20 mg/kg, introperitoneal) daily for 5 consecutive days induced leukemia-cell differentiation in APL leukemic mice.

物理化学性质&存储条件

分子量	325.38
分子式	C18H15NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-ethyl-N-(4-oxonaphthalen-1(4H)-ylidene)benzenesulfonamide

参考文献

1. Wei Wei, et al. Oncotarget. 2016 Jan 26;7(4):3873-83.

2. Wirakiat W, et al. Life Sci. 2020 Oct 1;258:118227.

PRDX1 inhibitor H7 (Peroxiredoxin I inhibitor H7)

生物&药学活性

物理化学性质&存储条件

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PRDX1 inhibitor H7 (Peroxiredoxin I inhibitor H7)

生物&药学活性

物理化学性质&存储条件

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