PRDX1 inhibitor 15

Chemical Structure : PRDX1 inhibitor 15

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货号: PC-22249Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PRDX1 inhibitor 15 is a potent, selective and covalent peroxiredoxin (PRDX1) inhibitor with IC50 of 0.35 uM, covalently binds to Cys-173 of PRDX1 with KD of 0.37 uM, shows antiproliferative potency against colon cancer cells.
PRDX1 inhibitor 15 displays weak inhibitory effects on PRDX2-PRDX6.
PRDX1 inhibitor 15 dose-dependently decreased the mitochondria membrane potential of SW620 cells, probably due to ROS induced by PRDX1 inhibition, leading to cell apoptosis.
PRDX1 inhibitor 15 displayed potent antitumor efficacy with superior safety to celastrol. colorectal cancer cell xenograft model.

物理化学性质&存储条件

分子量	576.78
分子式	C35H48N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 1-(3-((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexa-methyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicen-2-yl)urei-do)cyclobutane-1-carboxylate

参考文献

1. Yang Li, et al. J Med Chem. 2024 Apr 28. doi: 10.1021/acs.jmedchem.4c00023.