PRC1 inhibitor RB-3 |CAS:2396639-11-3 Probechem Biochemicals

Chemical Structure : PRC1 inhibitor RB-3

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PRC1 inhibitor RB-3 (RB-3)

货号: PC-38305Not For Human Use, Lab Use Only.

PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.
RB-3 bind to RING1B by inducing the formation of a hydrophobic pocket in the RING domain.
RB-3 decreases the global level of H2A ubiquitination (IC50=1.6 uM) and induces differentiation in leukemia cell lines and primary AML samples.
RB-3 represents a valuable chemical tool to study PRC1 biology.

物理化学性质&存储条件

分子量	417.893
分子式	C24H20ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)-

参考文献

1. Shukla S, et al. Nat Chem Biol. 2021 Jul;17(7):784-793.

PRC1 inhibitor RB-3 (RB-3)

生物&药学活性

物理化学性质&存储条件

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PRC1 inhibitor RB-3 (RB-3)

生物&药学活性

物理化学性质&存储条件

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