PR5-LL-CM01 |CAS:1005307-86-7 Probechem Biochemicals

Chemical Structure : PR5-LL-CM01

CAS No.: 1005307-86-7

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PR5-LL-CM01

货号: PC-61791Not For Human Use, Lab Use Only.

PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM.
PR5-LL-CM01 displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8.
PR5-LL-CM01 exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666.
PR5-LL-CM01 significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo.

物理化学性质&存储条件

分子量	401.518
分子式	C23H27N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N6-(2-(dimethylamino)ethyl)-N4-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

参考文献

1. Prabhu L, et al. Oncotarget. 2017 Jun 20;8(25):39963-39977.
2. Muniyandi A, et al. Sci Rep. 2023 Jan 31;13(1):1747.

PR5-LL-CM01

生物&药学活性

物理化学性质&存储条件

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PR5-LL-CM01

生物&药学活性

物理化学性质&存储条件

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