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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-PR-924
PR-924

Chemical Structure : PR-924

CAS No.: 1416709-79-9

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PR-924 (IPSI, PR 924, PR924)

货号: PC-60963Not For Human Use, Lab Use Only.

PR-924 is a potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PR-924 is a potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM).
    PR-924 shows weak activity toward LMP2 and no detectable activity toward β1, β2, or MECL1.

    物理化学性质&存储条件

    分子量 618.734
    分子式 C37H38N4O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((R)-1-(((S)-3-(1H-indol-3-yl)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide

    参考文献

    1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47.

    2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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