欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-PR-619
PR-619

Chemical Structure : PR-619

CAS No.: 2645-32-1

加入收藏

PR-619 (PR619)

货号: PC-20403Not For Human Use, Lab Use Only.

PR-619 (PR619) is a broad-spectrum, reversible deubiquitinating enzymes (DUBs) inhibitor with IC50 of 3.93 uM-8.87 uM.

规格 价格 库存 数量
25 mg ￥880 In stock
50 mg ￥1380 In stock
100 mg ￥2180 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PR-619 (PR619) is a broad-spectrum, reversible deubiquitinating enzymes (DUBs) inhibitor with IC50 of 3.93 uM-8.87 uM.
PR-619 showed limited activity against other families of proteases, including representative examples of other families of cysteine proteases.
PR-619 increased caspase-8 ubiquitination and caspase-8 enzymatic activity and sensitized normal fibroblasts to TRAIL-mediated apoptosis.
PR-619 reduced Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction.

物理化学性质&存储条件

分子量 223.27
分子式 C7H5N5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,6-diaminopyridine-3,5-bis(thiocyanate)

参考文献

1. Altun M, et al. Chem Biol. 2011 Nov 23;18(11):1401-12.

2. Crowder RN, et al. J Biol Chem. 2016 Mar 11;291(11):5960-5970.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: