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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Alkylator/Crosslinker-PR-104A
PR-104A

Chemical Structure : PR-104A

CAS No.: 680199-06-8

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PR-104A (SN27858)

货号: PC-23373Not For Human Use, Lab Use Only.

PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin, alcohol metabolite of phosphate proagent PR-104, which shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin, alcohol metabolite of phosphate proagent PR-104, which shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells.

物理化学性质&存储条件

分子量 499.29
分子式 C14H19BrN4O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethyl methanesulfonate

参考文献

1. Moradi Manesh D, et al. Blood. 2015 Sep 3;126(10):1193-202.

2. McKeage MJ, et al. BMC Cancer. 2012 Oct 25;12:496.

3. Adam V Patterson, et al. Clin Cancer Res. 2007 Jul 1;13(13):3922-32.

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