PQR-530 |CAS:1927857-61-1 Probechem Biochemicals

Chemical Structure : PQR-530

CAS No.: 1927857-61-1

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PQR-530 (PQR530, PQR 530)

货号: PC-35552Not For Human Use, Lab Use Only.

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.

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10 mg	￥2380	In stock
25 mg	￥3980	In stock
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生物&药学活性

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.
PQR-530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.

物理化学性质&存储条件

分子量	407.42
分子式	C18H23F2N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine

参考文献

1. Brandt C, et al. Neuropharmacology. 2018 Aug 3;140:107-120.

PQR-530 (PQR530, PQR 530)

生物&药学活性

物理化学性质&存储条件

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PQR-530 (PQR530, PQR 530)

生物&药学活性

物理化学性质&存储条件

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