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首页-小分子抑制剂&激动剂-Others-Other Targets-PQ529
PQ529

Chemical Structure : PQ529

CAS No.: 1215088-73-5

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PQ529 (PQ-529)

货号: PC-23789Not For Human Use, Lab Use Only.

PQ529 is a selective glutaminyl cyclase (QC, QPCT) / isoenzyme of glutaminyl cyclase (isoQC, QPCTL) inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PQ529 is a selective glutaminyl cyclase (QC, QPCT) / isoenzyme of glutaminyl cyclase (isoQC, QPCTL) inhibitor.
PQ529 induces significant increase of CCL2 mRNA for the doses of 0.625 and 2.5 µM in primary murine glia cells.
PQ529 reduced pE1-CCL2 secreted from murine and human primary macrophages.
PQ529 reduced the number of infiltrating monocytes dose-dependently in thioglycollate-induced peritonitis model.

物理化学性质&存储条件

分子量 350.38
分子式 C19H18N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidine-2,4-dione

参考文献

1. Cynis H, et al. EMBO Mol Med. 2011;9:545–58.

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