PQ-10 | PDE10A inhibitor | Probechem Biochemicals

Chemical Structure : PQ-10

CAS No.: 927691-21-2

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PQ-10 (PDE10A inhibitor PQ10, PQ10)

货号: PC-61348Not For Human Use, Lab Use Only.

PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
100 mg		Get quote

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生物&药学活性

PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.
PQ-10 displays 53-fold and 68-fold selectivity over PDE3A and PDE3B, respectively.
PQ-10 selectively inhibits colon tumor cell growth with IC50 of 0.1-28 uM.
PQ-10 selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress β-catenin levels and T-cell factor (TCF) transcriptional activity in colon tumor cells.

物理化学性质&存储条件

分子量	403.442
分子式	C22H21N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

参考文献

1. Li N, et al. Oncogene. 2015 Mar 19;34(12):1499-509.

2. Chappie TA, et al. J Med Chem. 2007 Jan 25;50(2):182-5.

PQ-10 (PDE10A inhibitor PQ10, PQ10)

生物&药学活性

物理化学性质&存储条件

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PQ-10 (PDE10A inhibitor PQ10, PQ10)

生物&药学活性

物理化学性质&存储条件

参考文献

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