PPTN trifluoroacetate salt |CAS:2187367-09-3 Probechem Biochemicals

Chemical Structure : PPTN trifluoroacetate salt

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PPTN trifluoroacetate salt

货号: PC-35051Not For Human Use, Lab Use Only.

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.

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1 g		Get quote

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生物&药学活性

PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM.
PPTN inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

物理化学性质&存储条件

分子量	589.534
分子式	C31H25F6NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(piperidin-4-yl)-phenyl)-7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid trifluoroacetate salt

参考文献

1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168.

2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68.

3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42.

4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9.