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首页-小分子抑制剂&激动剂-Others-Other Targets-PPTD free base
PPTD free base

Chemical Structure : PPTD free base

CAS No.: 1048-17-5

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PPTD free base

货号: PC-25882Not For Human Use, Lab Use Only.

PPTD free base is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PPTD free base is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8.

物理化学性质&存储条件

分子量 335.45
分子式 C21H25N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-phenethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

参考文献

1. Takafumi Hara, et al. bioRxiv. [Preprint]. 2025 Oct 23:2025.10.23.682519.

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