PP5 inhibitor P053 | PP5 inhibitor | Probechem Biochemicals

Chemical Structure : PP5 inhibitor P053

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PP5 inhibitor P053 (Compound P053)

货号: PC-21296Not For Human Use, Lab Use Only.

PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity.

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生物&药学活性

PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity.
PP5 inhibitor P053 does not bind to PP2A.
PP5 inhibitor P053 significantly inhibits cell proliferation in VHL-null ccRCC cells, 786-O and A498 compared to normal epithelial renal cell HK2 as well as VHL-positive ccRCC cell lines Caki-1 and Caki-2.
PP5 inhibitor P053 induces extrinsic apoptosis in clear cell renal cell carcinoma.

物理化学性质&存储条件

分子量	342.41
分子式	C18H18N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-benzylphenyl)-3,5-dimethylisoxazole-4-sulfonamide

参考文献

1. Ahanin EF, et al. Cell Chem Biol. 2023 Oct 19;30(10):1223-1234.e12.

PP5 inhibitor P053 (Compound P053)

生物&药学活性

物理化学性质&存储条件

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PP5 inhibitor P053 (Compound P053)

生物&药学活性

物理化学性质&存储条件

参考文献

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