POL3026 |CAS:918660-21-6 Probechem Biochemicals

Chemical Structure : POL3026

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POL3026 (POL 3026;POL-3026 )

货号: PC-61290Not For Human Use, Lab Use Only.

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay.

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生物&药学活性

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay; shows excellent plasma stability, high selectivity for CXCR4, favorable pharmacokinetic properties in vivo, has the potential to become a therapeutic compound for application in the treatment of HIV infections (as an entry inhibitor), cancer (for angiogenesis suppression and inhibition of metastasis), inflammation, and in stem cell transplant therapy.

HIV Infection

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物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-glutaminyl- L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)- L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl- L-arginyl-L-arginyl], cyclic (2?1)-disulfide

参考文献

1. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.

2. Moncunill G, et al. Mol Pharmacol. 2008 Apr;73(4):1264-73.

3. Lesniak WG, et al. Mol Pharm. 2015 Mar 2;12(3):941-53.

POL3026 (POL 3026;POL-3026 )

生物&药学活性

物理化学性质&存储条件

参考文献

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POL3026 (POL 3026;POL-3026 )

生物&药学活性

物理化学性质&存储条件

参考文献

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