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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-POL2438
POL2438

Chemical Structure : POL2438

CAS No.: 790223-00-6

POL2438 (POL 2438;POL-2438)

货号: PC-61291Not For Human Use, Lab Use Only.

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay; potently inhibits the T-tropic R4 viruses entry.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclo[3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)- L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)- L-ornithyl-L-cysteinyl-L-arginylglycyl-D-prolyl- L-arginyl-L-arginyl], cyclic (2?1)-disulfide

参考文献

1. DeMarco SJ, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8396-404.

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