PNU37883A | Kir6 inhibitor | Probechem Biochemicals

Chemical Structure : PNU37883A

CAS No.: 57568-80-6

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PNU37883A (PNU 37883A, PNU 37883 hydrochloride)

货号: PC-21738Not For Human Use, Lab Use Only.

PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively.
PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone with IC50 of 5 uM.
PNU37883A produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings.

物理化学性质&存储条件

分子量	381.99
分子式	C21H36ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N'-(Adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochloride

参考文献

1. Yi Cui, et al. Br J Pharmacol. 2003 May;139(1):122-8.

2. Guang-Yuan Mar, et al. Int J Exp Pathol. 2013 Feb;94(1):17-24.

PNU37883A (PNU 37883A, PNU 37883 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PNU37883A (PNU 37883A, PNU 37883 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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